I have a 2000 YZ426F with a 5" rear on it. I didn't have to remove the chain guide to install the tire and wheel. It takes a little patience, but it will go in there without dismanteling the bike. I had to off-set the rim a tad to allow the tire to clear the chain. It is a bit closer than I would like, but it will wear its way in. When I get new rubber, I may opt for a little narrower tire. I have a Maxxis 165 on the rear now. On my old TZ250 with a 5" rim I think I ran something like a 155. I may go that route to allow the chain a bit more clearance.
The 5" does flatten out the tread pattern better than the 4.25. The more rubber on the road at one time the better.
Later
Paul G
The 5" does flatten out the tread pattern better than the 4.25. The more rubber on the road at one time the better.
Later
Paul G